Pretty Cure protagonists Nagisa Misumi and Honoka Yukishiro are about as different as two people can get. Nagisa is the captain of the lacrosse team, a lover of food, and a hater of homework. Honoka loves to learn, working with the science club and earning the nickname "The Queen of Knowledge" from her fellow classmates. Their lives are unconnected until one day, when a mysterious star shower unites them.