Eddie Murphy

Donkey (voice)

Akbar

Prince Akeem / Clarence / Saul / Randy Watson

Self

Rudy Ray Moore

Self - Mr. Robinson (archive footage)

Henry Church

Self

Self

Himself, Self

Self

Jack McCall

Slide

Billy Ray Valentine

Donkey (voice)

Dave / Captain, Dave Ming Chang

Self

Self

Donkey (voice)

Maximillian / Pauly / Guido

Donkey (voice)

Donkey (voice)

Guest

Charlie Hinton

Self

Kelly Robinson

Pluto Nash

Officer Trey Sellars

Donkey (voice) (singing voice)

Dr. John Dolittle

Donkey (voice)

Sherman Klump, Sherman Klump / Buddy Love / Lance Perkins / Klump Family

Kit Ramsey / Jeffernson 'Jiff' Ramsey

Mushu (voice)

Sherman Klump / Buddy Love / Lance Perkins / Papa Klump / Mama Klump / Grandma Klump / Ernie Klump, Sherman Klump / Buddy Love / Papa / Mama / Grandma / Ernie

Det. Axel Foley

Host

Reggie Hammond

Quick

Prince Akeem / Clarence / Randy Watson / Saul

Det. Axel Foley

Himself, Self

Axel Foley

Himself - Host, Self - Host, Host

Lieutenant T.M. Landry

Mr. Robinson / Stevie Wonder / Bellboy / Various, Sammy Davis Jr. / Various, Bill Cosby / Raheem Abdul Muhammed / Various, Self - Host / Various, Self - Host / Buckwheat / Various, Various, Various (archive footage), Self - Host, Bruce Lee / Lt. Sam Cleveland / Various, Various / Secretary, Eddie Atari / Various, Self - Various Characters, James / Neighbor / Assaulant, Cupid / Various, Eddie Murphy, Self

Self

Host, Self