Maya Rudolph

Jean Dewberry

Dr. Vlam

Cynthia Utrom (voice)

Malvina Monroe, Malvina

Cass

Molly Novak

Connie

Co-Host

Daniela Paguro (voice)

Linda Mitchell (voice)

Nanny (voice)

Dr. Chakrabarti, Betty Hart, Jewel Thief, Norma

Naomi

Bubbles

Christine Davenport

Aunt Cass

Paula, Bonnie, Judge, Pornscape Residents, Ghost of Elizabeth Taylor, Miss Clinkscales, Bath Mat, Ghost of Whitney Houston, Principal Barren, The Pill, Exterminator #2, Nest, Gayle King, Connie, Susan, Parrot, Diane Birch

Smiler (voice)

Eunice

Deborah

Brinda

The Lounge Singer

Self - Guest

Griselda (voice)

Petunia Leeway

Aunt Cass (voice)

Self

Self

Deanne McKenzie

Self

Griselda Blanco

Leslie

Ava Alexander

Self

Self

Deanne McKenzie

Casey Janine Fitzpatrick

Self

Self

Rapunzel (voice)

Stacy

Self

U.S. Marshal Karen Haas

Jamilla

Chloe (voice)

Delivery Nurse

Self - Guest

Julia (voice)

Self - Host, Maya Rudolph, Self - Cameo (uncredited), Self - Various Characters, Self