4150 v. 4500 - The Battle of the Holley Carbs

Holley carbs have been known for years as the standard by which all racing carbs are measured, but today's question is this: CFMs being equal, is there any difference in power between the smaller-bore, narrower-set "street" style 4150 carb and the bigger-bore, wider-base 4500 series Dominator carb?